ISSN 1662-4009 (online)

ey0019.15-11 | Assorted Conditions | ESPEYB19

15.11. Evidence that ageing yields improvements as well as declines across attention and executive functions

J Verissimo , P Verhaeghen , N Goldman , M Weinstein , MT Ullman

Nat Hum Behav. 2022;6(1):97-110. doi: 10.1038/s41562-021-01169-7. PubMed ID: 34413509Brief summary: This cross-sectional study of adults (N=702) aged 58–98 measured cognitive abilities across a range of domains (alerting, orienting and executive inhibitory networks) by use of a computer-based Attention Network Test. In non-linear regression models, while efficiency of the ale...

ey0019.10-15 | Pathogenesis | ESPEYB19

10.15. Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

M Fasolino , GW Schwartz , AR Patil , A Mongia , ML Golson , YJ Wang , A Morgan , C Liu , J Schug , J Liu , M Wu , D Traum , A Kondo , CL May , N Goldman , W Wang , M Feldman , JH Moore , AS Japp , MR Betts , Consortium HPAP , RB Faryabi , A Naji , KH Kaestner , G Vahedi

Nat Metab. 2022 Feb;4(2):284-299. https://pubmed.ncbi.nlm.nih.gov/35228745/Brief Summary: This study used three high-throughput single-cell technologies to generate a pancreatic islet cell atlas from 24 organ donors with type 1 diabetes (T1D), autoantibody positive and healthy donors. The most remarkable finding was that a subset of exocrine ductal cells appears to acquire a signature of to...